Serum oxidant/antioxidant status of patients with systemic lupus
Taysi S, Gul M, Sari RA, Akcay F, Bakan N.
Department of Biochemistry, Faculty of Medicine, Ataturk University, Erzurum,
The levels of malondialdehyde and ceruloplasmin, and superoxide dismutase
activity were higher, while transferrin concentration and the activities of
glutathione peroxidase and catalase were lower in serum of patients with
systemic lupus erythematosus (n=24) compared with healthy controls (n=20).
Disease activity index correlated positively with serum malondialdehyde level
(r=0.47, p<0.05), erythrocyte sedimentation rate (r=0.41, p<0.05) and C-reactive
protein concentration (r=0.41, p<0.05), while it correlated negatively with
serum superoxide dismutase (r=0.42, p<0.05) and glutathione peroxidase (r=-0.44,
p<0.05) activities in patients. No such correlations were found in healthy
control subjects. It remains to be seen whether correlations found between
disease activity score and serum malondialdehyde level, and also activities of
serum superoxide dismutase and glutathione peroxidase enzymes observed in the
present study may be used to predict prognosis in patients with systemic lupus