Ways to Elevate Glutathione

Dr. Jimmy Gutman, World-Wide Expert in the field of Glutathione Research gives us these insights:

Oral Glutathione

•             Available in pill form or powder form

•             Cannot be passed through most cell walls

•             Has no effect in raising intracellular GSH

•             Has no measurable effect on immunologic                      

                 Parameters

Intravenous Glutathione

•        In its intact form, GSH is effectively delivered though IV

•        Glutathione has a short half-life intravenously and is rapidly delivered to tissues

•        Some GSH may be sequestered in the liver for subsequent future utilization, but unlike glutathione precursors, it cannot be stored for later conversion into GSH when demands are made

•        Intact glutathione (intravenous) also down-regulates cellular glutathione manufacture by acting through negative-feedback inhibition

Inhaled Glutathione

•        Inhaled glutathione is an effective delivery system to the pulmonary tree where it can be

      absorbed to the tissues in direct contact with the nebulized agent

•        Systemic glutathione levels are minimally effected through this application

Cysteine

•        Cysteine, a non-essential amino acid, may raise intracellular GSH

•        However, supplementation with cysteine or L-cysteine may lead to hypercysteinemia and potential toxicity

•        Cysteine is also easily oxidized in the digestive tract which limits its absorption into the plasma and cells

Milk Thistle 

             Worldwide glutathione expert, Dr. Jimmy Gutman, states

•         “Milk thistle’s active ingredients are a group of chemicals called Silymarins, which function                   

              as weak Glutathione precursors.”

Liposomal Glutathione

•        Liposomes are double membrane lipid vesicles

•        They have been widely studied as important carriers in controlling the spatial and temporal distribution of bioactive molecules for therapy

•        Dr. Gutman, GSH expert, states, “In regards to liposomal cysteine, there is not a single published article demonstrating its efficacy.”

NAC (N-acetyl cysteine)

•        NAC has been utilized for years by medical practitioners to raise intracellular GSH for clinical studies

•        NAC is more commonly seen in nutritional and body building supplements today

•        NAC provides a rapid 'peak' of GSH which is measured only in hours, with eventual drop of GSH, occasionally even below baseline levels 

•         For sustained effect NAC must be ingested several times per day

•        Adverse reactions as well as death have resulted from the use of NAC:

•        Fatal anaphylactoid reaction to  N-acetylcysteine: caution in patients with asthma.  Appelboan AV, Dargan Pl, Knighton J     Toxicol (Phila). 2008 Nov;46(9):921

•        Cardiac arrest following therapeutic administration of N-acetylcysteine for paracetamol overdose.  Cassidy N, Tracey JA, Drew SA 

•        According to research at the University of Virginia, N-acetylcysteine (NAC), an anti-oxidant                commonly used in nutritional and body-building supplements, can form a red blood cell-derived molecule that makes blood vessels think they are not getting enough oxygen.

•        This leads to pulmonary arterial hypertension, PAH, a serious condition characterized by high blood pressure in the arteries that carry blood to the lungs.

•        The results appear in the September issue of the Journal of Clinical Investigation.

•        “NAC fools the body into thinking that it has an oxygen shortage. We found that an NAC product formed by red blood cells, known as a nitrosothiol, bypasses the normal regulation of oxygen sensing.  It tells the arteries in the lung to ‘remodel’; they become narrow, increasing the blood pressure in the lungs and causing the right side of the heart to swell.”  (Dr. Ben Gaston, U.V., a Children’s Hospital pediatrician and researcher who led the study)

Whey Proteins

•        Whey proteins vary greatly in the type and amount of their protein make-up, as well as their degree of denaturization (processing with heat and mechanical stress can destroy bioactivity)

•        Therefore the level of bioavailability of glutathione precursors as well as the level of bioactivity is usually not substantial

Immunocal the Nutraceutical

•        Immunocal is a patented, highly concentrated, whey protein isolate; non-denatured 90% pure bioactive protein

•        This guarantees the highest level of GSH-promoting activity available

•        The only concentrate patented for its immuno-sustaining and glutathione-enhancing effects 

•        It is the culmination of over 25 years of research at McGill University (the equivalent of “Harvard” in Canada)

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