GSH and Cognitive Performance, Mood, Memory
Whey protein rich in alpha-lactalbumin increases the ratio of plasma tryptophan to the sum of the other large neutral amino acids and improves cognitive performance in stress-vulnerable subjects
The bovine protein rich in alpha-lactalbumin, increases the plasma ratio of tryptophan to the other large neutral amino acids and in vulnerable subjects raises cortisol concentration and improves mood under stress.
Am J Clin Nutr 2000 June; 71(6): 1536-44.Diet rich in alpha-lactalbumin improves memory in unmedicated, recovered depressed patients and matched controls.
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Oxidative stress and reduced brain glutathione (GSH) levels have been reported in psychiatric illnesses including schizophrenia and bipolar disorder. However the role of GSH in cognitive impairment in the illness remains unclear. Treatment of Sprague-Dawley rats and C57Bl/6 mice with 2-cyclohexene-1-one (CHX) dose-dependently reduced striatal and frontal cortical GSH levels similar to those in schizophrenia. In both species, GSH depletion resulted in disruption of short-term spatial recognition memory in a Y-maze test. In conclusion, GSH depletion induces cognitive impairment, which may be relevant to the role of GSH in psychiatric illnesses.
PMID: 19061918 [PubMed - indexed for MEDLINE]
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